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This modification extends peptide half-life and maintains receptor interaction over longer periods

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While taste 1 receptors function as dimers to sense sweet or umami, taste 2 receptors detect a large variety of bitter tastants ( in vivo relevance of sweet TR activation on incretin secretion still remains unclear, since others have been unable to demonstrate functional activity of T1R2/T1R3 in primary cultured L cells or in perfused intestinal preparations ( in vivo studies in animals and humans consistently failed to show effects of artificial sweeteners on plasma incretins (32)

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