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The C20 fatty diacid moiety enabling albumin binding extends the pharmacokinetic half-life to approximately 6-7 days, making once-weekly research dosing protocols practical

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0.1% RGN-259 (Thymosin 4) ophthalmic solution promotes healing and improves comfort in neurotrophic keratopathy patients in a randomized, placebo-controlled, double-masked Phase III clinical trial

In tendon explant and fibroblast systems, it is linked to focal adhesion signaling and cell migration behavior