Many have advocated that the associations between low mood, suicidal behavior and anti-obesity drugs such as GLP-1RAs are confounded by the pre-existing higher prevalence of neuropsychiatric disorders observed in people living with obesity compared with the general population 236
Acting on widely expressed GLP-1 receptors, these drugs influence multiple signaling pathways involved in metabolism, cardiovascular health, neuroprotection, and anti-inflammatory responses
Confronting Barriers Eric Topol (36:58): Yeah, no, that's a very important point
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Maintaining physical activity : Regular exercise generates body heat and helps preserve lean muscle mass, which is metabolically active and contributes to thermogenesis
GLP-1 agonists slow down gastric emptying which could potentially impact the amount of oral medication absorbed by the body.