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Dosing in the Phase 3 Diabetes Trial (TRANSCEND-T2D-1) A1C reduction: -1.7% to -2.0% across doses (from baseline 7-9.5%) Weight loss at 12 mg: 16.8% (-36.6 lbs) at 40 weeks Discontinuation due to adverse events was relatively low across all doses, similar to the patterns seen in TRIUMPH-4 The diabetes population typically loses less weight on GLP-1 drugs than the obesity-only population, which is consistent with what was observed: ~17% weight loss in T2D vs
Although I 2 is commonly used for assessment of heterogeneity, it is not a perfect measure and its value depends on the precision and size of the included studies
It has converted them from using the compounded versions to the brand
Journal of Sleep Research: "Effects of Weight Loss on Obstructive Sleep Apnea Severity: 10-year Follow-Up Study." Journal of Sleep Research, 2014
Vitamin D plays a crucial role in calcium absorption, bone health, immune function, and muscle strengthall particularly relevant during weight loss
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