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Currently, no trials have examined the impact of GLP-1 agonists on normal weight, non-diabetic subjects and no trial either of GLP-1 agonists alone or in combination with biologics, has included patients with psoriatic arthritis

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Patients with severe renal or hepatic impairment whether dose adjustments or avoidance are necessary will depend on the pharmacokinetic data presented in the eventual retatrutide SmPC