The article says research indicates estrogen influences GLP-1 signaling at multiple levels, including appetite centers and insulin-producing beta cells
These characteristics are similar to those reported for GABAergic Gipr KO mice, which also had attenuated weight gain on HFD exposure, with reduced fat and lean mass 5,11
A.MccarthyS.KramerM.MullerS.LihmJ.et al (2018)
Doumouras AG, Wong JA, Paterson JM, et al
The study reported Friday, which Novo Nordisk calls REDEFINE 1, enrolled people with obesity or who are overweight and have at least one health condition the same group for whom Wegovy and Zepbound are approved for weight loss
UPFs are also linked to imbalance in the gut microbiome, which increases the risk of weight gain