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Stress, the endoplasmic reticulum, and insulin resistance

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Results showed berberine reduced body weight by 2.05 kg (approximately 4.5 pounds) and BMI by 1.04 kg/m compared to placebo or lifestyle intervention alone

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However, there are still challenges that need to be addressed, such as the optimization of properties, reliable characterization methods, safety evaluation, nanoparticles that might lead to unintended consequences like nano-pollution and cytotoxicity and regulatory aspects related to nanomedicines targeting skin cancer [176, 179]

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