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ED 50 values from different study designs (single-dose 96-hour endpoint vs

Grade 3 or greater ventricular tachyarrhythmias were reported in 0.2%, Grade 3 or greater atrial fibrillation and atrial flutter were reported in 3.7%, and Grade 3 or greater cardiac failure was reported in 1.3% of 4,896 patients who received IMBRUVICA in clinical trials, including in patients who received IMBRUVICA in unapproved monotherapy or combination regimens

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Tirzepatide activates both GLP-1 and GIP receptors, creating stronger appetite suppression than semaglutide alone for some patients

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