The Contraindication Is About Cancer, Not Hormone Levels Wegovy carries a boxed warning stating that in rodents, semaglutide causes thyroid C-cell tumors at clinically relevant exposures, and that whether it causes thyroid C-cell tumors including medullary thyroid carcinoma in humans has not been determined
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The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation
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If any answer is no, discuss adjustments with your provider
Importantly, dysesthesia rarely led to treatment discontinuation and tended to resolve or stabilize over time