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What it is / mechanism Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) that selectively agonizes the ghrelin receptor (GHS-R1a) on pituitary somatotrophs, triggering a signaling cascade that produces a pulsatile release of growth hormone, while also blunting somatostatin the body's natural GH-inhibiting signal

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