Peptides are different biologic tools with different questions around source, formulation, route, regulatory status, and evidence
It does not just suppress or stimulate
(2007) Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH4-10
doi:10.1016/j.yebeh.2015.11.014
In mammals, two of the peptides have been cloned and characterized the 27 aa gastrin-releasing peptide (GRP) and the 10 aa neuromedin B (NMB), which act through their specific G-coupled receptors
Oral versions such as capsules or troches are more convenient, but absorption through the digestive tract is far less consistent, so the amount that actually reaches circulation can vary widely