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Adequate levels of L- Glutathione are necessary to provide important antioxidant protection needed by cells, to help eliminate toxic metabolic waste products and to support the immune system

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therefore, drugs targeting EPHB1, PI3K/AKT, and Bcl-2/Bcl-xL, which are involved in the apoptosis resistance pathway, have been developed 28

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Recently, it was found that the Gram-negative bacterium Pseudomonas aeruginosa (PA) can lead to the loss of intracellular GPX4 after infection of the host, resulting in ferroptosis [46]