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Yamano E, Sugimoto M, Hirayama A, Kume S, Yamato M, Jin G, et al

Quality assessment The methodological quality of randomized controlled trials ( n = 4) was assessed independently by two reviewers using the Cochrane Risk of Bias tool version 2 (RoB 2)

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Yes, with appropriate caution

A meta-analysis published in The Lancet Diabetes & Endocrinology (N=17 prospective studies) found that individuals in the highest quintile of circulating IGF-1 had a 25% increased relative risk of colorectal cancer compared to the lowest quintile [12]