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Likewise, the ROCKET-AF, 12 ARISTOTLE, 13 and ENGAGE AF-TIMI 48 14 trials compared rivaroxaban, apixaban, and edoxaban, respectively, against warfarin for the prevention of AF-associated thromboembolic events

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Current Clinical Evidence: What Studies Actually Show Controlled trials using semaglutide or tirzepatide for diabetes and weight loss have documented mood and cognitive effects as secondary observations, not primary endpoints