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[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

Baseline characteristics among the three groups were well-matched for age, gender, body mass index, duration since diagnosis, prior use of any therapies (DMARDs, biologics, steroids) and clinical scores indicating disease activity