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Clinical pharmacology studies demonstrate that despite oral bioavailability of less than 1% compared to nearly complete absorption with subcutaneous injection, properly formulated oral tablets containing appropriately higher absolute doses achieve therapeutic blood concentrations sufficient for clinical appetite suppression, gastric emptying modulation, and metabolic effects comparable to injectable administration

contact your GP or trial clinician promptly for persistent palpitations or unexplained fatigue

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Receptors can be deleted in specific tissues with Cre-Lox or knocked down by local administration of antisense RNA such as in specific brain nuclei (19)

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