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Monitoring Protocol Watch for: Persistent vomiting Abdominal pain Visual symptoms Excessive weight loss Weakness / falls / sarcopenia signals This is good practical OPD monitoring and is aligned with real-world use, though exact frequency should be individualized

While metformin can cross the BBB, it has poor solubility and its brain concentration is low to induce sufficient neuroprotective action 19,67

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Interventions that appear successful in cell cultures frequently utilize concentrations that are biologically impossible to achieve in a living human

[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Jeong W.Y., Kwon M., Choi H.E., Kim K.S