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Actuallly, our body stores most of our B12 reserves in the liver as adenosyl B12, and converts it to methyl B12 whenever needed

Established that NAMPT-mediated NAD+ biosynthesis is regulated by CLOCK/BMAL1 circadian transcription factors, creating a circadian oscillation of NAD+ that drives SIRT1, SIRT3, and SIRT6 activity

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Parry Strong A, Haeusler S, Weatherall M, Krebs J (2016) Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomized trial

This synergy likely stems from attacking the healing process through multiple distinct pathways simultaneously

The agency could accept the recommendation, reject it or request more information