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Montefiore Einstein Neurosurgery Spine TUMOR Lab A systematic review of TXA in surgery for spinal metastases reports a reassuring safety profile, but highlights the need for large-scale RCTs: Ali Haider Bangash, MBBS Jessica Ryvlin Mitchell Fourman Yaroslav Gelfand Saikiran Murthy Reza Yassari Rafael De la Garza Ramos @NASSspine @ElsOrthopaedics #orthopedics #spine To view or add a comment, sign in Tissue quality matters more than timing when it comes to ACL restoration with the BEAR Implant

The mild increase in DNA fragmentation at 200 g/mL is consistent with the elevated necrosis at that concentration: membrane disruption exposes chromatin to extracellular nucleases and divalent metal ions, accelerating fragmentation independently of ROS 51

Limited evidence suggests only modest effects in specific populations, with results highly variable and often reversible upon discontinuation

Homogeneous Add-Mix-Read Assay for Total and Oxidized Glutathione A wide variety of compounds can induce intracellular formation of reactive oxygen species (ROS) and the resulting cellular damage can eventually lead to apoptosis or necrosis

Increase running and other forms of high-impact exercise gradually