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Gastrointestinal adverse reactions, including diarrhea, were the most common reason for treatment discontinuation in clinical trials, with approximately 4-7% of patients discontinuing due to GI events

Epub 2013 Jan 15

Although RID is an imperfect measure with various limitations, the researchers modified standard RID calculations to include parameters for bioavailability and long-acting formulation

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Understanding why OTC options fall short requires looking beyond marketing claims to your individual metabolic picture