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It just has to come from the right place

While published research generally reports favorable tolerability, comprehensive long-term human safety studies have not yet been completed

Perhaps the curiosity of interested parties has surpassed existing scientific evidence

*Correspondence: Hani El-Nezami, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Seek medical attention promptly if you experience symptoms that could suggest serious underlying conditions, including: Unexplained weight loss or persistent fatigue Jaundice (yellowing of skin or eyes), abdominal pain, or swelling Easy bruising or bleeding , or unusual skin rashes Night sweats , fever, or enlarged lymph nodes Reduced urine output , significant swelling in legs or ankles Persistent itching without obvious skin cause These symptoms may indicate liver disease, haematological disorders, or renal impairmentconditions that can elevate B12 and require specialist assessment

In comparison, most manufacturers recommend storing lyophilized powder at a lower temperature, away from bright light