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This modification is shared with tirzepatide and other modern incretin analogs, and is essential for achieving the extended duration of action required for once-weekly dosing

For patients considering GLP-1 weight loss, medical weight loss, semaglutide, or tirzepatide, side-effect management should be part of the treatment plan from the beginning

Typical results: Expect losses of anywhere from 21 to 32 percent of body weight, per studies published in Nature Medicine and elsewhere

They can be taken only with a prescription

Round numbers reduce reading errors at the syringe

The retatrutide data are very solid, says Daniel Drucker, a university professor of medicine at the University of Toronto, adding that the trial shows excellent weight-loss and A1C results