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(Summarized from Czimmerer et al., 2023
Noise exposure can lead to loss of many afferent synapses and degeneration of type 1 SGNs within weeks and months after noise exposure (Kujawa and Liberman, 2009), even when the exposure results in no permanent threshold shift or HC loss
Exendin-4 enhances osteogenic differentiation of adipose tissue mesenchymal stem cells through the receptor activator of nuclear factor-kappa B and osteoprotegerin signaling pathway
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For instance, TEPP-46 and microbial metabolite-based therapies (e.g., butyrate, itaconate) exhibit robust efficacy in animal models but have yet to be systematically evaluated in human autoimmune populations
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