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This depends on successful completion of the remaining TRIUMPH Phase 3 trials, most of which are expected to report results throughout 2026

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

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What you might notice: Mild appetite reduction, particularly in the 24 to 72 hours after injection Slight nausea, especially after eating large or fatty meals A subtle sense of fullness that arrives sooner than expected Some people notice absolutely nothing at this stage Weight change in week one is typically minimal, zero to two pounds