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Asimakopoulou, A., Panopoulos, P., Chasapis, C

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Rather than representing a purely cutaneous condition, PsO appears to be a systemic metabolicinflammatory disease in which insulin resistance, adipokine imbalance, and altered gutendocrine signaling contribute to immune dysregulation long before the onset of clinically overt joint involvement (7)

A mixture of siRNA and Lipofectamine 2000 was added to 6-well plates, and incubated for 6 h, and then the medium was replaced with fresh medium containing 10% serum and antibiotics, and the cells were incubated for 48 h