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However, this method is hugely limited by the high cost

Long-term hyperglycemia and acute blood glucose fluctuations induce oxidative stress, causing endothelial dysfunction in diabetic patients [50, 249]

in: PubMed | Google Scholar 1 Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

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Consistent with the low GLP-1R signal in the PBMCs and splenocytes, treatment of mouse whole blood or splenocyte cultures with 50 nM exenatide did not alter LPS-induced TNF- release (22)

Hiroshima J Med Sci