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We also explored whether this association varied across different symptom profiles

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The American College of Gastroenterology's 2021 guideline on irritable bowel syndrome management issued a conditional recommendation against the use of probiotics for global IBS symptoms, citing very low overall quality of evidence.[8] IBS is not the same as GLP-1 constipation, but it overlaps in terms of dysmotility-driven symptoms, and the guideline tone signals appropriate caution about probiotic claims in this neighborhood

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