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Exenatide, a 39-amino acid peptide, is the first GLP-1R agonists approved by the US FDA in 2005 and EMA in 2007

This possibility is consistent with our previous observation in which the triagonist enhanced Ca 2+ influx in the human pancreatic beta cell line 1.1B4, and inhibition of PLC activity with U73122 significantly attenuated the triagonist-induced increases in intracellular Ca 2+ concentration [9]

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Central administration of GLP-1 and GIP decreases feeding in mice

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