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The role of GLP-1 receptor agonists in managing type 2 diabetes

There are a few limitations associated with this study

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The common dosages are 100 mg and 200 mg capsules, each suited for different patient needs and severity of symptoms

The double-blind STRIDE trial, conducted at 112 outpatient clinics in North America, Asia and Europe from October 2020 to July 2024, randomized 792 participants (median age 68 years, 25% women, 68% White) with T2D and PAD with intermittent claudication (Fontaine stage IIa) as well as an ankle-brachial index of 0.90 (mean 0.75) or toe-brachial index 0.70 (mean 0.48) to either once-weekly doses of subcutaneous semaglutide (n=396) or placebo (n=396) for 52 weeks