retatrutide phase 2 weight loss is investigational and is not FDA approved. In TRANSCEND-T2D-1, investigators randomized 537 adults with type diabetes inadequately controlled by diet and exercise in a 40-week, double-blind, placebo-controlled 3 trial The New Gold Standard: Retatrutide

Basing this calculation on corrected bodyweight (adjusted or ideal) or FFM, or setting an absolute protein target of 80120 g/day (or 16 %24 % energy on a 2000 kcal/day diet) have been proposed as alternative approaches, although a clear consensus on the optimal method has yet to be reached [27]

Updated June 2026 Author: Allison Jones, F-NP Medically reviewed by Dr

Frequently asked questions Are GLP-1 patches safe

SLU-PP-332

Instead of the natural hormone lasting minutes, semaglutide persists for roughly a week

The trial enrolled 445 adults with obesity or overweight who also had knee osteoarthritis, and it tracked outcomes over 68 weeks