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But, it can change based on how bad the deficiency is and what the patient needs

The dosing of bupropion in Contrave is lower than typical antidepressant dosing, so a direct switch isnt straightforward

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313 Loss-of-function mutations in LAMP2B disrupt lysosomal degradation, leading to the accumulation of autophagic vacuoles, mitochondrial dysfunction, and impaired cellular clearance, ultimately resulting in cardiomyocyte hypertrophy and contractile dysfunction