Retatrutide is a synthetic peptide that modulates the endocannabinoid system, regulating metabolism, inflammation, and neurological function, setting it apart as a promising treatment option
Marx N, Deanfield JE, Mann JFE, Arechavaleta R, Bain SC, Bajaj HS, Bayer Tanggaard K, Birkenfeld AL, Buse JB, Davicevic-Elez Z, Desouza C, Emerson SS, Engelmann MDM, Hovingh GK, Inzucchi SE, Jhund PS, Mulvagh SL, Pop-Busui R, Poulter NR, Rasmussen S, Tu ST, McGuire DK
This is not the same as saying GLP-1 medications cause muscle wasting. What the evidence actually shows is that rapid weight loss without adequate protein intake or resistance training can lead to meaningful lean mass reductions alongside fat loss
Substance use, including tobacco, alcohol, opioid, and illicit drug use disorders, should be addressed to maximize GLP-1 benefits
Tame Stress Stress can mess with your blood sugar and make you crave comfort food
Currently, two ongoing clinical trials are investigating the role of GLP-1 RAs in IBD management, that would lead to further knowledge: a French study (ID NCT05196958) evaluating the safety and efficacy of GLP-1 RAs in treatment of DM2 in overweight IBD patients (115), and an American study (ID NCT06774079) comparing the efficacy of GLP-1 RAs tirzepatide versus diet in CD patients (116)
