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NO and redox state Not only does NO regulate mitochondrial function and biogenesis via interactions with signaling molecules and the electron transport chain, but it also regulates the production of mitochondrial free radicals (reactive oxygen species and reactive nitrogen species) (Moncada and Erusalimsky, 2002

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Winn NC, Wolf EM, Cottam MA, Bhanot M, Hasty AH

This precise dynamic mechanism can be totally disrupted during cholesterol lithogenesis, since hepatic bile supersaturated with cholesterol delivers large amounts of solubilized cholesterol to the gallbladder epithelial cells

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