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: New supplemental guidance planned on computer software assurance for AI-based systems used in drug manufacturing and clinical investigations

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mutations in genes (for example wnk1 or wnk4), regulating na-cl cotransporters (ncc), na-k-cl cotransporters (nkcc2), or the renal outer medullary potassium (romk) channel have been identified as causative in this condition

Consistently, a higher proportion of patients compared with gene carriers exhibited elevated PGA levels (74%)

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While shared DEGs may serve as core therapeutic targets, drug-specific DEGs likely represent molecular signatures underlying the unique regulatory profiles of each agent