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Safety and Tolerability As with many metabolic therapies, the most commonly reported side effects in the Retatrutide trial included gastrointestinal symptoms such as nausea, diarrhea, constipation, vomiting, and decreased appetite, patterns seen with many gut-hormone modulators

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By inhibiting alpha-glucosidase, alpha-glucosidase inhibitors slow the absorption of glucose from the gut, blunting the post-meal rise in blood glucose

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