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[10] These actions are hypothesized to be due to Ipamorelin's potential to modulate hGH and IGF-1 production

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This synergistic mechanism enhances insulin secretion, reduces appetite, and improves metabolic flexibility

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These comparative studies represent the defining research application of Ipamorelins selectivity and have produced the core literature establishing which GH secretagogue biological effects are GH-dependent versus prolactin or cortisol-mediated