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When lost quickly, the underlying scaffolding disappears, and the skin as well as the supporting collagen and elastin may not adapt in time, leading to sagging, deeper folds, and a deflated appearance often described as Ozempic face. Common facial changes associated with GLP-1-driven weight loss include: Sunken cheeks and temples Sagging jowls and jawline Deepening of nasolabial folds (smile lines) Downturned corners of the mouth Flattened or elongated lips Excess skin and loss of facial volume These changes result not only from fat loss but also from the skins decreased elasticity that occurs with both aging and accelerated weight reduction

doi: 10.1002/jcp.22196 95 HsuJ-YCrawleySChenMAyupovaDALindhoutDAHigbeeJet al

Compounded semaglutide contains the same active pharmaceutical ingredient as brand-name formulations and works through identical GLP-1 receptor mechanisms

The STEP (Semaglutide Treatment Effect in People with obesity) trials showed that participants lost approximately 1520% of their body weight over 68 weeks, with body composition analyses indicating that roughly 2040% of the total weight lost was lean mass

Nevolat is the brand name for a generic version of liraglutide, replacing the now-discontinued Saxenda