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This work was also supported by the National Key Research and Development Program of China (2018YFA0507001, 2018YFA0507000, 2018YFA0508100), the National Natural Science Foundation of China grants 31770898 (G.S.), 31900895 (L.Y.) and 81872915 (M.-W.W.), the National Science and Technology Major Project Key New Drug Creation and Manufacturing Program of China (2018ZX09735-001) and China Postdoctoral Science Foundation (2017M622365)

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HSA-binding DARPin consists of two internal ankyrins with flanking constant N- and C-terminal capping repeats, each repeat forming a -turn followed by two anti-parallel -helix and an unstructured loop that binds to the -turn of the next ankyrin repeat (Fig

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