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Despite this rise, HbA1c mostly remained below the initial value at one year

Certain GLP-1s can worsen existing retinopathy in people with diabetes

These pathways play a crucial role in its wide-ranging therapeutic effects, extending the benefits of GLP-1RAs beyond metabolic diseases

Glycemia reduction in type 2 diabetes - glycemic outcomes

For many people with obesity, GLP-1 medications combined with lifestyle changes lead to significantly greater and more sustainable weight loss than lifestyle measures alone

437,438 This involves modulating the cell apoptosis process, for example, by decreasing the Bax/Bcl-2 ratio in cardiomyocytes, reducing cytochrome C release, and caspase activation