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Cells increase their contraction of F-actin in response to extracellular forces and remodel their entire cytoskeleton through a process involving Rho-GTPases (such as Rho or Rac1), myosin activity, and ROCK19

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A., Mabrouk, M., Abd-Rabou, A

However, as there are records of coffee enemas causing severe side effects and death, you should always speak with a doctor if youre considering an enema