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Abstract Background Desensitization of G proteincoupled receptors (GPCRs) refers to a rapid attenuation of responsiveness that occurs with repeated or continuous exposure to agonists

Food & Drug Administration (FDA-d)

If you experience headaches on day 2 post-injection, that is information

For the 5 mg/kg IP injection, the estimated mean AUC by 3 h (AUC 03hr ) was 20.4 mgmin/mL, which accounted for more than 95% of the estimated total AUC (AUC 0- ) of 21.0 mgmin/mL

That can mean fewer doses to reach the same effect

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