Biologics and devices in periodontal reconstructive therapy
Neuroprotective peptides (Cerebrolysin, Thymosin Beta-4) directly support ganglion cell survival
The identification of exendin-4 from Gila monster (Heloderma suspectum) saliva as a stable GLP-1 mimetic enabled appetite suppression and glycemic control in metabolic disease, driving the development of long-acting GLP-1 analogues and unimolecular agents that co-activate GLP-1 and GIP receptors (Mller et al., 2025)
However, the effect on endogenous GLP-1 secretory patterns following treatment in adolescents is unknown
Semaglutide GLP-1 helps to suppress appetite, slow stomach emptying, and improve insulin sensitivity, making it easier to reduce calorie intake and manage hunger
This indirect approach can help avoid some of the drawbacks associated with direct growth hormone supplementation