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The study showed that the administration of 10.000 ugr of hydroxocobalamin nasal drops twice weekly was associated with a significant increase in vitamin B12 serum levels over the course of 3 months, starting from a median of 328 pmol/l (range 244429) to 973 pmol/l (range 4731,476)

Higher Upfront Cost: While the cost per dose might be higher than oral supplements, the less frequent dosing schedule can sometimes balance out the expense over time

These mechanisms involve a delay in DNA damage repair, promotion of apoptosis, inhibition of angiogenesis, and regulation of the tumor microenvironment

By implementing these strategies, individuals who have undergone bariatric surgery can maintain optimal vitamin B12 levels and reduce the risk of deficiency-related complications