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Secondary endpoints for semaglutide included pharmacokinetics during dose escalation (C trough [1 week after the fourth dose at each dose level]) and at steady state (1.0 mg) (AUC 0168 h , C max , t 1/2 , CL/F, Vz/F), safety, tolerability, and pharmacodynamics

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GLP-1RAs demonstrated a favorable safety profile, with no meaningful increase in severe hypoglycemia or acute pancreatitis observed across trials

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