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They share a common peptide ancestor, but they are structurally and mechanistically different enough that understanding the distinction is essential for experiment design and result interpretation

PMID: 26236730 Published Research Highlights Discovery 1973 Tripeptide Identified in Human Serum Pickart and Thaler first identified the GHK sequence in human plasma, discovering a tripeptide that prolonged survival of normal liver cells and stimulated growth in cell culture models

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Hegedus L, Moses AC, Zdravkovic M, Le TT, Daniels GH

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