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How MSCs May Influence Autism Biology In preclinical models, MSC therapy has been associated with: Reduced neuroinflammation Decreased microglial activation Increased production of neurotrophic factors Enhanced synaptic plasticity Improved neuronal survival In mouse models of autism, MSC treatment has been linked to improvements in social interaction and reductions in repetitive behaviors

10.1007/s00109-008-0426-z 90

Chronic pain often involves nervous system sensitization, metabolic dysfunction, nutrient depletion, or low-grade inflammation that may not appear on standard imaging or routine laboratory tests

The extensive preclinical research foundation, favorable preclinical safety profile, and preliminary human experience suggest BPC-157 warrants continued investigation as a potential therapeutic agent for tissue repair and regeneration

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Comparing outcomes from a localized SubQ injection (lumbar/glute) versus a distant SubQ injection (abdomen) can yield powerful data on the compound's site-enhancement effects