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Scientific Reports , 14 (1), 5002

Enhanced Mitochondrial Biogenesis : Explored for the activation of PGC-1 via SIRT1, leading to superior cellular respiration and energy production

doi:10.1038/s41591-022-02026-4

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One way that insulin resistance affects hormones is by disrupting the function of the hypothalamic-pituitary-adrenal (HPA) axis, which is a complex system that regulates the bodys stress response.In insulin resistance, the body produces more cortisol, a stress hormone that can lead to a range of negative effects, including weight gain, increased appetite, and decreased insulin sensitivity