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GLP-1 receptor activation has been shown to counteract these mechanisms by reducing macrophage infiltration in adipose tissue, suppressing NF-Bmediated cytokine release, and promoting an anti-inflammatory immune profile (49)

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2023 Sep:215:115636

While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism

"Most of the vision side effects appear to resolve when the medication is stopped." CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER Kipnis emphasized that these drugs should only be taken under the care of a healthcare professional and that "good and consistent follow-up for dose adjustments with monitoring for side effects" is critical

From 24.2% at 48 weeks to 28.7% at 68 weeks