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No, they are mechanistically distinct

The improved functioning of the BBB, enhanced clearance of metabolites and protein fragments implicated in AD from the brain - an astrocyte-dependent mechanism primarily occurring during sleep [14] - and enhanced insulin signaling, suggested to play a role in AD [33], present additional mechanisms by which melatonin may impact AD pathology

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Safety Considerations and Who Should Expect Extended Low-Dose Phases Patients with sensitive GI systems, those over age 65, or those with concurrent medications may benefit from slower titration

The FDA prescribing information requires at least 72 hours (3 days) between tirzepatide doses when making any schedule adjustments

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