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Patients with AP often exhibit increased lipid peroxidation, and vitamin E can help reduce cell membrane damage by decreasing the formation of peroxidized lipids, thereby minimizing pancreatic cell injury

2.12 Involvement of collateral vessel formation in exercise-mediated alleviation of atherosclerosis The ameliorative effect of exercise training on atherosclerosis is manifested not only through the regulation of traditional factors but also via the promotion of collateral vessel formation, which compensates for blood flow in ischemic tissues

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You do not need to restart from the lowest dose if you have been stable on a higher dose, though your provider may adjust based on their clinical judgment